Table 1.

ASK1-related diseases and pathologies.

Organ/tissue	Related diseases	Related pathologies	References
Nervous system	Alzheimer's disease	Neuronal death	[13]
	Parkinson's disease	Neuronal death	[14]
	Brain ischemia	Neuronal death	[15]
	Multiple sclerosis	Inflammation	[16]
Liver	Hepatocarcinogenesis	Apoptosis	[17]
Heart	Hypertrophy, remodeling Cardiac injury	Cardiomyocyte apoptosis, interstitial fibrosis Capillary endothelial apoptosis	[18, 19]
			[20]
Stomach	Gastric cancer	Cell proliferation	[21]
Skin	Skin tumorigenesis	Apoptosis, inflammation	[22]
Immune system	Infection	Septic shock	[6]