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Tissue levels of Na-ketoprofen (μg) detected by chromatography following local intradermal (LIT) or intramuscular (IM) administration, modified with permission from [23].
| Time (hours) | Skin | Muscle | Articular tissue | |||
|---|---|---|---|---|---|---|
| LIT | IM | LIT | IM | LIT | IM | |
| 0 | nd | nd | nd | nd | nd | nd |
| 0.5 | 124.9 | 4.8 | 1.5 | 33.3 | 25.8 | 18.6 |
| 1 | 42.3 | t | 3 | t | 19.3 | 0.3 |
| 2 | 15.6 | t | 23.8 | t | 10.8 | t |
| 4 | 10.9 | t | 19.3 | t | 8.3 | t |
| 7 | t | nd | 100.6 | t | 6.2 | t |
| 10 | t | nd | 102.2 | t | 7 | t |
| 24 | nd | nd | 14.9 | nd | 0.8 | nd |
nd = not detectable; t = trace.
