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. Author manuscript; available in PMC: 2013 Jan 6.
Published in final edited form as: Org Lett. 2011 Dec 19;14(1):422–425. doi: 10.1021/ol203242r

Table 1.

Comparisons between Organocatalysts in an Aldol Reaction, in Water at rt

graphic file with name nihms345448u2.jpg
catalyst yielda (%) anti:synb eec (%)
PQS-proline (2) 93 92:8 96
proline C-4 ester (6A) <5 – –
proline (6B) 0 – –
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proline C-4 ester (6A)		 graphic file with name nihms345448t2.jpg
proline (6B)		 graphic file with name nihms345448t3.jpg
Barbas’ catalyst 7b (6C)
a

Combined yield of isolated diastereomers.

b

Determined by 1H NMR of the crude product.

c

Determined by chiral-phase HPLC analysis for anti-product.