Table 2.

Representative PQS-proline (2)-Catalyzed Reactions^a

entry	product	time (h)	yieldb (%)	ant i:sync	eed (%)
1	9a	30	88	82:18	90
2	9b	18	90	90:10	90
3	9c	48	74	86:14	92
4	9d	36	80	83:17	91
5	9e	18	85	85:15	79
6	9f	30	80	90:10	97
7	9g	36	82	68:32	86
8	9h	18	85	89:11	75
9	9i	36	82	84:16	86
10	9j	24	90	90:10	91

^aThe reactions were performed with aldehyde (0.1 mmol), ketone (0.5 mmol) and catalyst 2 (0.01 mmol) at rt.

^bCombined yield of isolated diastereomers.

^cDetermined by ¹H NMR of the crude product.

^dDetermined by chiral-phase HPLC analysis for anti-product.