Table 2.
Number of patients | Gender | Age (years) | Before treatment | |||
---|---|---|---|---|---|---|
Men/Women | TSBAb (%) | TSAb (%) | TBII (%) | |||
(I) 34 TSBAb-positive patients with hypothyroidism | ||||||
| ||||||
Ia | 17 | 5/12 | 42 ± 17 | 94 ± 6 | 146 ± 10 | 95 ± 5 |
Ib | 15 | 4/11 | 45 ± 16 | 90 ± 9 | 136 ± 8 | 92 ± 7 |
Ic | 2 | 1/1 | 38, 45 | 98, 97 | 100, 98 | 96, 95 |
Ia+Ib+Ic | 34 | 10/24 | 43 ± 18 | 92 ± 7 | 140 ± 9 | 94 ± 7 |
| ||||||
(II) 98 TSAb-positive Graves' patients with hyperthyroidism | ||||||
IIa | 10 | 3/7 | 40 ± 16 | 9 ± 8 | 839 ± 421 | 76 ± 15 |
IIb | 13 | 3/10 | 42 ± 17 | 10 ± 11 | 846 ± 195 | 68 ± 16 |
IIc | 73 | 18/55 | 44 ± 16 | 10 ± 10 | 746 ± 390 | 56 ± 18 |
IId | 2 | 0/2 | 40, 48 | 2, 5 | 1625, 852 | 76, 58 |
IIa+IIb+IIc+IId | 98 | 24/74 | 43 ± 17 | 10 ± 9 | 775 ± 396 | 57 ± 17 |
Values are means ± SD. I, Ia, Ib, Ic, II, IIa, IIb, IIc, and IId correspond to those in Table 1. No differences of gender and ages were noted among I, Ia, Ib, Ic, II, IIa, IIb, IIc, and IId. No differences of TSAb-, TSBAb-, and TBII-activities were noted among Ia, Ib, and Ic and among IIa, IIb, IIc, and IId.
All of the 34 TSBAb-positive patients with hypothyroidism had strongly positive TSBAb (85–103%, mean ± SD = 92 ± 7%) (Ia+Ib+Ic). Some of them had weakly positive TSAb. Their TSAb activity ranged from 92% to 240%. The TSAb activities were 180–240% in 7 (21%) of the 34 TSBAb-positive patients with hypothyroidism and were less than 180% in the other 27 patients (79%). Seven (21%) of the 34 TSBAb-positive patients with hypothyroidism had positive TSAb. TSBAb-positive patients with hypothyroidism had narrow distribution of TSBAb (82–104%, 92 ± 7%) and TSAb (92–240%, 140 ± 9%). All of the 98 Graves' patients with hyperthyroidism had positive TSAb (250–1795%, 775 ± 396%) (IIa+IIb+IIc+IId). Some of them had TSBAb. The TSBAb activities were +40–+52% in 11 (11%) and were less than +40% in the other 87 patients (89%). Graves' patients with hyperthyroidism had wide distributions of TSAb (250–1795%, 775 ± 396%) and TSBAb (−28–+52%, 10 ± 9%).