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HIV and Kaposi Sarcoma. HHV-8 genes activated by HIV-Tat.
| HHV-8 genes | Effects | Other properties |
|---|---|---|
| vGPCR (ORF 74) | Constitutively activates GPCR Promotes synthesis of VEGF |
Oncogenic Angiogenic |
| vBcI2 (ORF 16) | Antiapoptotic activity Inhibits bax |
Oncogenic |
| vIRF-1 (ORF K9) | Interferon regulatory factor homolog Activates the c-myc oncogene |
Antagonizes IFN-mediated antiviral immunity |
