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Current clinical trials with rapalogs in sarcomas.
| Agent | Human trials | Clinical benefit rate (CR, PR, and SD) | Notes |
|---|---|---|---|
| Temsirolimus | GIST ASCO 2010 |
GIST = 4/15 (27%) STS = 2/15 (13%) |
Refractory GIST |
| Temsirolimus | Phase II STS Mayo Clinic |
5% | |
| Sirolimus | Kaposi sarcoma | 15/15 (100%) | Posttransplant KS Dermal lesions |
| Ridaforolimus | Phase II-STS | 61/212 (29%; 2% PR) | IV formulation |
| Ridaforolimus | SUCEED trial | PFS: HR = 0.69 (P < 0.0001) (22.4 versus 14.7 weeks) | Maintenance after ChemoRX |
