Table 1.

Brain areas with decreased and increased binding (BP_ND) of GABA_A receptors in patients with Tourette syndrome (analysis used global normalization of BP_ND)

Cluster size	Regions (Brodmann areas)	x	y	z	Z-value
	Brain areas with decreased BPND
5702	Left nucleus accumbens, putamen, caudate nucleus	−8	10	−7	6.69
	Left inferior frontal gyrus (BA 47)
	Right putamen, nucleus accumbens, caudate nucleus	18	8	−5	5.77
	Right insula (anterior and posterior)
	Right transverse temporal gyrus (BA 41)
	Right inferior frontal gyrus (BA 47)
	Left and right thalamus (pulvinar, centromedian, dorsomedian nuclei)	−11	−25	14	5.77
131	Right precuneus (BA 7)	13	−58	53	4.29
181	Left amygdala and hippocampus	−18	−9	−22	3.97
765	Left postcentral gyrus (BA 1, 2, 3)	−34	−34	54	3.96
1136	Left superior occipital gyrus (BA 19)	−31	−75	29	3.87
	Right cuneus (BA 19)	8	−75	31	3.75
	Left medial occipital gyrus (BA 19)	−38	−75	12	3.36
222	Right amygdala and hippocampus	20	−11	−22	3.85
670	Left fusiform gyrus (BA 19)	−22	−60	−7	3.63
	Brain areas with increased BPND
1953	Left and right SN and left periaqueductal grey	−3	−27	−10	4.83
256	Right posterior cingulate gyrus, sulcus calloso-marginalis (BA 31)	17	−13	41	4.20
1656	Left and right cerebellum, dentate nuclei	−8	−54	−29	4.10
		6	−56	−28

Cluster size = number of voxels; x, y, z = stereotaxic coordinates in Talairach space; coordinates indicate the distance in millimetres from the origin (anterior commissure), with positive x indicating right, positive y indicating anterior and positive z indicating dorsal.