Table 2. Raw data: the relative contribution of Wnt1-expressing progenitors marked at distinct developmental timepoints to MbDA Neurons.
Raw Quantitative Data describing the relative contribution of Wnt1-expressing progenitors marked at distinct developmental time points to MbDA neurons. The data indicate 1) the average percentage ± the standard deviation (SD) of Wnt1-derived MbDA neurons (βgal+/TH+) when compared to total MbDA neurons (βgal+/TH+ and βgal−/TH+ neurons) 2) the average number ± SD of Wnt1-derived MbDA neurons (βgal+/TH+) and 3) the average number of total MbDA neurons (βgal+/TH+ and βgal−/TH+ neurons) in a given region.
| Time of Tamoxifen Administration | E7.5 | E8.5 | E9.5 | E10.5 | E11.5 | E12.5 | E13.5 |
|---|---|---|---|---|---|---|---|
| Wnt1-Derived MbDA Neurons (percentage ± SD) | 26 ± 6% | 32 ± 22% | 49 ± 13% | 13 ± 17% | 36 ± 8% | 14 ± 14% | 7 ± 9% |
| Wnt1-Derived MbDA Neurons (count ± SD) | 172 ± 43 | 181 ± 101 | 315 ± 75 | 83 ± 114 | 220 ± 52 | 97 ± 97 | 37 ± 48 |
| MbDA Neurons (count ± SD) | 637 ± 59 | 600 ± 71 | 652 ± 63 | 623 ± 34 | 596 ± 52 | 656 ± 38 | 543 ± 33 |
| Wnt1-Derived VTA MbDA Neurons (percentage ± SD) | 26 ± 8% | 37 ± 26% | 51 ± 9% | 15 ± 21% | 32 ± 9% | 19 ± 12% | 10 ± 11% |
| Wnt1-Derived VTA MbDA Neurons (count ± SD) | 64 ± 19 | 71 ± 32 | 128 ± 10 | 34 ± 49 | 73 ± 20 | 50 ± 36 | 20 ± 21 |
| VTA MbDA Neurons (count ± SD) | 252 ± 44 | 212 ± 46 | 254 ± 20 | 233 ± 11 | 231 ± 17 | 247 ± 34 | 204 ± 11 |
| Wnt1-Derived RRF MbDA Neurons (percentage ± SD) | 28 ± 10% | 34 ± 14% | 50 ± 31% | 13 ± 23% | 37 ± 15% | 9 ± 14% | 2 ± 3% |
| Wnt1-Derived RRF MbDA Neurons (count ± SD) | 9 ± 3 | 9 ± 5 | 13 ± 8 | 4 ± 6 | 8 ± 3 | 2 ± 3 | 0 ± 1 |
| RRF MbDA Neurons (count ± SD) | 34 ± 4 | 26 ± 8 | 29 ± 6 | 26 ± 7 | 24 ± 10 | 29 ± 10 | 27 ± 5 |
| Wnt1-Derived SNc MbDA Neurons (percentage ± SD) | 28 ± 6% | 29 ± 21% | 47 ± 14% | 12 ± 15% | 39 ± 8% | 12 ± 15% | 5 ± 8% |
| Wnt1-Derived SNc MbDA Neurons (count ± SD) | 99 ± 24 | 101 ± 65 | 174 ± 59 | 45 ± 58 | 134 ± 34 | 45 ± 59 | 17 ± 26 |
| SNc MbDA Neurons (count ± SD) | 351 ± 17 | 362 ± 29 | 370 ± 59 | 364 ± 45 | 341 ± 31 | 379 ± 15 | 313 ± 30 |
| Wnt1-Derived Rostral MbDA Neurons (percentage ± SD) | 26 ± 6% | 30 ± 21% | 48 ± 9% | 14 ± 18% | 40 ± 10% | 13 ± 14% | 6 ± 11% |
| Wnt1-Derived Rostral MbDA Neurons (count ± SD) | 73± 11 | 79 ± 48 | 132 ± 38 | 38 ± 51 | 101 ± 27 | 37 ± 40 | 15 ± 26 |
| Rostral MbDA Neurons (count ± SD) | 284 ± 24 | 272 ± 23 | 279 ± 52 | 268 ± 30 | 253 ± 29 | 283 ± 8 | 218 ± 13 |
| Wnt1-Derived Intermediate MbDA Neurons (percentage ± SD) | 28 ± 9% | 32 ± 25% | 52 ± 16% | 14 ± 20% | 35 ± 8% | 17 ± 14% | 7 ± 6% |
| Wnt1-Derived Intermediate MbDA Neurons (count ± SD) | 44 ± 18 | 41 ± 24 | 77 ± 15 | 28 ± 23 | 49 ± 10 | 31 ± 29 | 10 ± 10 |
| Intermediate MbDA Neurons (count ± SD) | 151 ± 29 | 139 ± 24 | 154 ± 23 | 143 ± 22 | 138 ± 3 | 167 ± 27 | 135 ± 14 |
| Wnt1-Derived Caudal MbDA Neurons (percentage ± SD) | 27 ± 5% | 34 ± 21% | 49 ± 16% | 12 ± 16% | 32 ± 8% | 14 ± 14% | 7 ± 7% |
| Wnt1-Derived Caudal MbDA Neurons (count ± SD) | 55 ± 16% | 61 ± 29 | 105 ± 29 | 28 ± 40 | 66 ± 15 | 29 ± 28 | 12 ± 12 |
| Caudal MbDA Neurons (count ± SD) | 202 ± 37 | 188 ± 25 | 219 ± 22 | 212 ± 32 | 205 ± 26 | 206 ± 26 | 190 ± 35 |
| Wnt1-Derived Dorsal MbDA Neurons (percentage ± SD) | 27 ± 5% | 28 ± 11% | 53 ± 15% | 13 ± 20% | 29 ± 3% | 11 ± 11% | 5 ± 6% |
| Wnt1-Derived Dorsal MbDA Neurons (count ± SD) | 34 ± 4 | 31 ± 7 | 73 ± 25 | 18 ± 28 | 38 ± 4 | 13 ± 14 | 6 ± 6 |
| Dorsal MbDA Neurons (count ± SD) | 127 ± 6 | 115 ± 17 | 138 ± 12 | 142 ± 24 | 132 ± 23 | 119 ± 4 | 110 ± 5 |
| Wnt1-Derived Intermediate MbDA Neurons (percentage ± SD) | 26 ± 5% | 36 ± 30% | 46 ± 13% | 12 ± 17% | 35 ± 11% | 14 ± 13% | 7 ± 6% |
| Wnt1-Derived intermediate MbDA Neurons (count ± SD) | 52 ± 21 | 60 ± 42 | 90 ± 23 | 24 ± 35 | 55 ± 12 | 30 ± 31 | 10 ± 8 |
| Intermediate MbDA Neurons (count ± SD) | 202 ± 63 | 179 ± 23 | 198 ± 4 | 174 ± 21 | 159 ± 23 | 198 ± 33 | 148 ± 42 |
| Wnt1-Derived Ventral MbDA Neurons (percentage ± SD) | 54 ± 40% | 31 ± 21% | 49 ± 14% | 13 ± 16% | 40 ± 9% | 16 ± 16% | 7 ± 10% |
| Wnt1-Derived Ventral MbDA Neurons (count ± SD) | 86 ± 25 | 90 ± 52 | 152 ± 52 | 41 ± 51 | 122 ± 40 | 54 ± 53 | 21 ± 33 |
| Ventral MbDA Neurons (count ± SD) | 233 ± 152 | 306 ± 43 | 317 ± 70 | 307 ± 41 | 304 ± 34 | 339 ± 13 | 285 ± 25 |