Table 3.
Effects of epicatechin (50 mg/kg) on ethanol-induced gastric ulcer area (mm2) in rats (n = 7) pretreated with glibenclamide (K+ ATP channels blocker, 3 mg/kg) or yohimbine (α 2-receptor antagonist, 3 mg/kg). The results are expressed as the mean ± SEM and analyzed by an unpaired t-test. *P < 0.05 and **P < 0.01 compared to the control group, which was orally treated with vehicle.
| Pretreatment (i.p) | Treatment (p.o) | Gastric ulcer area (mm2) | Percentage of gastroprotection |
|---|---|---|---|
| Vehicle | Vehicle | 599.11 ± 98.78 | — |
| Epicatechin | 243.33 ± 61.05* | 59.39 | |
|
| |||
| Glibenclamide | Vehicle | 134.13 ± 16.03 | — |
| Epicatechin | 21.27 ± 6.00** | 84.14 | |
|
| |||
| Yohimbine | Vehicle | 602.64 ± 102.27 | — |
| Epicatechin | 1028.81 ± 171.94 | 0 | |