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. 2012 Mar 31;3(3):327–335. doi: 10.18632/oncotarget.468

Figure 1. Schematic diagram of the overlapping distributions of molecular abnormalities at 11p15, WTX, WT1 and CTNNB1 in Wilms tumor.

Figure 1

The percentage of sporadic tumors with each abnormality in our series is indicated in brackets. CTNNB1 mutations occur predominantly in tumors with WT1 mutations. WTX mutations occur predominantly in tumors with 11p15 defects. WT1-mutant tumors often have pUPD 11p15 while H19 epimutation, the other class of 11p15 defect, is not seen in this context. WTX mutations are infrequent in tumors with WT1 or CTNNB1 mutations. (pUPD: paternal uniparental disomy)