TABLE 3.

PAIRWISE COMPARISONS OF PYROTAG SEQUENCING RESULTS OF THE 16S RRNA GENE AMONG THE EXPERIMENTAL GROUPS BEFORE AND AFTER SUBTRACTION OF OTU THAT SHARED 3% OR GREATER SIMILARITY TO READS FROM THE NEGATIVE CONTROL GROUPS

	P Value*	P Value (with negative subtracted)*
Smoker control vs. cystic fibrosis	0.0005	0.0003
Smoker control vs. COPD (GOLD 4)	0.0007	0.0008
Smoker control vs. nonsmoker control	0.8891	0.8597
Cystic fibrosis vs. COPD (GOLD 4)	0.0003	0.0009
Cystic fibrosis vs. nonsmoker control	0.0005	0.0005
COPD (GOLD 4) vs. nonsmoker control	0.0027	0.0022
Negative control vs. nonsmoker control	0.0011	N/A
Negative control vs. Smoker control	0.0006	N/A
Negative control vs. COPD (GOLD 4)	0.0019	N/A
Negative control vs. cystic fibrosis	0.0044	N/A

Definition of abbreviations: COPD = chronic obstructive pulmonary disease; GOLD = Global Initiative for COPD; OTU = operational taxonomic units.

^*All P values except for the smoker control versus the nonsmoker control remain significant after Bonferroni correction for multiple comparisons.