TABLE 4.

TOP FIVE BACTERIAL SPECIES ASSOCIATED WITH EACH SAMPLE GROUP

Species Name	Biserial Correlation Coefficient	P Value	Q Value
Cystic fibrosis
Alcaligenaceae unclassified	0.55	0.0186	0.291883
Pseudomonas unclassified	0.55	0.0064	0.164345
Pseudomonas unclassified	0.53	0.0083	0.203868
Pseudomonadaceae unclassified	0.48	0.0382	0.405884
Alcaligenaceae unclassified	0.47	0.0314	0.405884
COPD (GOLD 4)
Lactobacillus unclassified	0.69	0.0003	0.011299
Burkholderia unclassified	0.69	0.0004	0.014123
Lactobacillus unclassified	0.65	0.0007	0.023262
Lactobacillus unclassified	0.62	0.0008	0.025108
Burkholderiales unclassified	0.61	0.0024	0.07136
Smoker control*
Aquabacterium unclassified	0.51	0.0115	0.234045
Rhodocyclaceae unclassified	0.43	0.0424	0.405884
Acidovorax caeni	0.52	0.0496	0.424557
Nonsmoker control
Comamonadaceae unclassified	0.61	0.0032	0.09039
Comamonadaceae unclassified	0.55	0.0038	0.102226
Brevundimonas diminuta	0.53	0.0103	0.234045
Diaphorobacter unclassified	0.52	0.0114	0.234045
Comamonadaceae unclassified	0.52	0.0172	0.291883

Definition of abbreviations: COPD = chronic obstructive pulmonary disease; GOLD = Global Initiative for COPD.

Bold species represent those that passed the false-discovery rate q value of <0.05.

^*Smoker control group only had three species whose P value was significant.