TABLE 1.
COMPREHENSIVE SUMMARY COMPARING EFFECTS REGULATED BY RELM-α AND ARGINASE 1 IN EXPERIMENTAL ASTHMA AND HELMINTH INFECTIONS
| Relm-α |
Arginase I |
|||
| Property | Asthma | Parasites | Asthma | Parasites |
| Expression | Up-regulated: Epi Cells, Mac, and Eos (RNA only) | Up-regulated: Epi Cells, Mac, and Eos (protein + RNA) | Up-regulated: bone marrow–derived cells | Up-regulated: bone marrow–derived cells |
| Urea concentrations | NA | NA | No | Yes |
| Antibody production | No | Yes | No | Yes |
| Eosinophilia | Model-dependent | Yes | No | Unknown |
| AHR | No | Unknown | Model-dependent (47, 48) | Unknown |
| Fibrosis | No | Yes | No | Yes |
| Granuloma | NR | Yes | NR | Yes |
| Mucus | No | Yes | No | Yes |
| Th1 cytokines | No | Unknown | Unknown | Unknown |
| Th2 cytokines | No | Inhibitory | No | Dual activating (60) and inhibitory (46) |
| Chemokines | No | Unknown | Unknown | Unknown |
Definition of abbreviations: AHR, airway hyperresponsiveness; Eos, eosinophils; Epi, epithelial; Mac, macrophages; NA, not assessed; NR, not relevant; Relm-α, resistin-like molecule–α.