TABLE 1.

AIRWAY CHARACTERISTICS BETWEEN UNEXPOSED MICE AND MICE WITH PRENATAL NICOTINE EXPOSURE

	Control	Nicotine
Characteristics	(n = 8)	(n = 8)
Total no. of airways	1,259	2,034*
Bronchi	468	723*
Bronchioles	791	1311*
Average airway diameter, μm
Bronchi	229.77 ± 135.37	237.86 ± 139.70
Bronchioles	84.77 ± 28.44	84.84 ± 25.36

C57BL6/J female mice were administered either untreated water or water containing 100 μg/ml nicotine before timed breeding and through gestation. Lungs were obtained from age-matched offspring at 8 weeks of age. The mice exposed to prenatal nicotine have a significantly greater number of bronchi and bronchioles compared with the unexposed control animals. Average airway diameter was not significantly different between groups (n = 8–9).

^*P < 0.05 compared to control.