Figure 1.

Effects of trans-4-{4-[3-(4-trifluoromethoxy-phenyl)-ureido]-cyclohexyloxy}-benzoic acid (t-TUCB) and Rolipram on tobacco smoke (TS) exposure–induced weight loss in spontaneously hypertensive (SH) rats. Body weight measurements were taken before and after smoke exposure each week. The weekly mean weights measured before smoke exposure each week are reported. The time course is presented for body weight changes of age-matched, non–TS-exposed animals as controls (open circles), TS-exposed animals treated with vehicle (solid squares), TS-exposed animals treated with soluble epoxide hydrolase inhibitors (sEHI) t-TUCB (solid triangles), and TS-exposed animals treated with Rolipram (open diamonds). Data are expressed as means ± SEM for 4–8 animals/group. wk, weeks. *P < 0.05, TS-exposed groups were significantly different from the control group. ^†P < 0.05, treatment group with sEHI t-TUCB was significantly different from the TS vehicle group.