Effects of t-TUCB and Rolipram on TS exposure–induced airspace enlargement. (A) Sections of the parenchyma from filtered air (Control), TS-exposed SH rats with vehicle treatment (TS vehicle), sEHI treatment (TS sEHI), or Rolipram treatment (TS Rolipram) were stained with hematoxylin and eosin. (B) Blinded quantification of mean linear intercept. *P < 0.05, TS-exposed groups were significantly different from the control group. †P < 0.05, treatment group with sEHI t-TUCB was significantly different from the TS vehicle group.