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. Author manuscript; available in PMC: 2012 Nov 1.
Published in final edited form as: J Immunol. 2011 Sep 30;187(9):4913–4919. doi: 10.4049/jimmunol.1101000

Figure 6. In vivo effects of OmCI in pigs.

Figure 6

Different amounts of OmCI were tested in a pig model of E. coli-induced sepsis. Five 15 kg pigs received the following boluses of OmCI: 22.5 mg (n = 1), 15 mg (n = 1), 7.5 mg (n = 2) or 3.75 mg (n = 1) prior to the induction of sepsis, and thereafter a continuous infusion of 0.5 mg OmCI/h. Two animals served as positive controls, receiving E. coli and saline (9 mg/ml). Blood samples were drawn at baseline (Tbasis), and then at 0 (T0), 30, 60, 120, 180 and 240 minutes. The effect of OmCI on the functional activity of the three C pathways is shown using the Wielisa assay. The data are expressed in % of a standard defined as 100% activity. Data points are given as single values or as mean with range for 7.5 mg dose and the E. coli positive control.