TABLE 2.
CANDIDATE GENES LOCATED WITH SIGNIFICANT (CHROMOSOME 9) AND SUGGESTIVE (CHROMOSOMES 3 AND 5) QUANTITATIVE TRAIT LOCI FOR HEART RATE TIME INDEX AND LOW-FREQUENCY TIME INDEX IN AXB/BXA RECOMBINANT INBRED STRAINS OF MICE
| SNPs |
RI HRTI* |
RI LFTI* |
|||||||||
| Location | |||||||||||
| QTL | Gene | rs No. | (Mbp) | Effect | AA Change | A/J Allele | B6 Allele | P Value | A/J Allele | B6 Allele | P Value |
| 3 | Slc7a11 | 3,022,958 | 50.205964 | A/G | † | 17,209 (766) | 11,180 (1,162) | 0.014 | 44.71 (2.50) | 32.73 (4.07) | <0.001 |
| 5 | Hvcn1 | 13,478,496 | 122.683604 | A/C | Glu65Ala | 11,358 (1,461) | 16,192 (890) | 0.010 | 30.85 (3.38) | 43.51 (2.75) | 0.018 |
| 9 | Thsd4 | 6,224,703 | 59.835173 | C/T | Met770Val | 18,417 (827) | 12,686 (962) | <0.001 | 48.57 (3.18) | 34.81 (2.74) | 0.004 |
| Tipin | 13,459,109 | 64.152234 | G/T | Cys265Phe | 18,201 (822) | 12,820 (1,014) | 0.001 | 49.86 (3.27) | 34.00 (2.39) | <0.001 | |
Definition of abbreviations: HRTI, heart rate time index; Hvcn1, hydrogen voltage-gated channel 1; LFTI, low-frequency time index; LOD, log of the odds ratio; Mbp, megabase pairs; QTL, quantitative trait loci; RI, recombinant inbred; rs, RefSNP accession number; Slc7a11, solute carrier family 7, member11; SNPs, single-nucleotide polymorphisms; Thsd4, thrombospondin type I, domain containing 4; Tipin, timeless interacting protein.
*
Mean (SEM).
†
Intron SNP.