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. 2012 Apr;46(4):541–550. doi: 10.1165/rcmb.2011-0306OC

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Figure 4. — Top 10 clusters of gene ontology categories and pathways enriched by genes dysregulated by LPS + DI (using PBS + TI as the reference group) in lungs. Groups were compared using significance analysis of microarray (LPS + DI versus PBS + TI and LPS + TI versus PBS + TI), and the lists of dysregulated genes were explored by Database for Annotation, Visualization and Integrated Discovery functional annotation clustering to assess significance of gene-term enrichment. Bars represent the log-transformed enrichment P value (modified Fischer's exact test) of each category for the LPS + DI versus PBS + TI comparison (dark gray) and for the LPS + TI versus PBS + TI comparison (light gray). The top 10 clusters are those with the highest enrichment score (calculated as the geometric mean of the enrichment P values of all categories within the cluster) for the LPS + DI versus PBS + TI comparison. The vertical dashed line represents the 0.05 significance threshold. TI, ventilation with TIs only.