Table 1. Significant interactions on HDL-C in multi-ethnic cohorts.

Test Stage	Cohorta	SNP 1				SNP 2				Pc d
		chr	posb	rsID	Genec	chr	posb	rsID	Genec
Discovery	ARIC EA	5	74656539	rs12916	HMGCR (3′ UTR)	15	58683366	rs1532085	40.8 k U LIPC	0.008
Fine Mapping	ARIC EA	5	74651084	rs3846662	HMGCR (Intron)	15	58680954	rs2043085	43.2 k U LIPC	0.002
Validation	MESA EA	5	74651084	rs3846662	HMGCR (Intron)	15	58582540	rs1973688	141.6 k U LIPC	0.006
Validation	FHS EA	5	74651864	rs55727654	HMGCR (Intron)	15	58666341	rs473422	57.8 k U LIPC	0.002
Validation	MESA HA	5	74602699	rs1423527	30.3 k U HMGCR	15	58718340	rs7163280	5.8 k U LIPC	0.04
Validation	ARIC AA	5	74685520	rs3761743	27.6 k D HMGCR	15	58736623	rs567838	LIPC (Intron)	0.004

^aEA denotes European American; HA denotes Hispanic American; AA denotes African American.

^bBuild 37.1 (GRCh37).

^cU indicates upstream of; D indicates downstream of.

^d P-value after Bonferroni correction.