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. 2012 May 24;8(5):e1002515. doi: 10.1371/journal.pcbi.1002515

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Dunn et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(a) A haematoxylin and eosin stained wax section of a murine colonic crypt. Scale bar = . (b) The cross-sectional model geometry, plotted against the axes used to mark cell -coordinates for the results presented. A linearly decreasing gradient of Wnt factors is imposed in the cross-sectional model, which is normalised to 1 at the base of the crypt, and 0 at the crypt collar. A threshold is prescribed such that cells in the region of insufficient Wnt factors are defined to be terminally differentiated. Thus, proliferating and non-proliferating epithelial cells are indicated in yellow and pink respectively, whilst non-proliferating stromal cells are indicated in green.

Inline graphic — (a) A haematoxylin and eosin stained wax section of a murine colonic crypt. Scale bar = . (b) The cross-sectional model geometry, plotted against the axes used to mark cell -coordinates for the results presented. A linearly decreasing gradient of Wnt factors is imposed in the cross-sectional model, which is normalised to 1 at the base of the crypt, and 0 at the crypt collar. A threshold is prescribed such that cells in the region of insufficient Wnt factors are defined to be terminally differentiated. Thus, proliferating and non-proliferating epithelial cells are indicated in yellow and pink respectively, whilst non-proliferating stromal cells are indicated in green.