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. 2012 May 24;8(5):e1002697. doi: 10.1371/journal.pgen.1002697

Figure 1. A novel mouse model of male-specific infertility.

Figure 1

A screen for ENU-induced recessive mutations that cause male-specific infertility was undertaken. (a) In one pedigree (PED-JP5), six infertile males were identified through matings to a total of four or more CD1 females each. A significant reduction in testis weight in mutant animals was noted (b, c), which was first observed at day 35 and remained consistently 60% of wild-type weight when compared at both day 70 (adulthood) and at around one year of age (days 300–365) (c). (+/+ = Wild-type, m/m = recessive mutant, bar = 2 mm, ** p = 0.0022).