Table 1. In vivo replication of DUVV-NL07.
| 8-week old BALB/c | 3-week old BALB/c | ||||||
| Day 7 | Day 10 | Total | Day 7 | Day 10 | Total | ||
| 106 | i.m. | −(0/5) | 107 (2/5)1 | 2/10 | 107 (2/5) | 106 (3/5)1 | 5/10 |
| TCID50/mouse | s.c. | 107 (2/5) | 107 (2/5)1 | 4/10 | −(0/5) | 108 (2/5)1 | 2/10 |
| 104 | i.m. | −(0/5) | 106 (3/5)1 | 3/10 | −(0/5) | 108 (1/5)1 | 1/10 |
| TCID50/mouse | s.c. | −(0/5) | 108 (1/5)1 | 1/10 | 104 (1/5) | −(0/5) | 1/10 |
| 102 | i.m. | −(0/5) | −(0/5) | 0/10 | −(0/5) | −(0/5) | 0/10 |
| TCID50/mouse | s.c. | −(0/5) | −(0/5) | 0/10 | −(0/5) | −(0/5) | 0/10 |
Viral RNA detected in the brain of animals (mean values expressed in copies/ml) infected with high, intermediate or low dose of DUVV-NL07 via peripheral route. The number of DUVV-NL07 RNA positive animals per total number of animals inoculated is indicated within brackets. Numbers in superscript indicate the amount of animals that developed paralysis in the respective groups.