Table 2. Virulence of DUVV-NL07, SHBRV-18 and RABV-PV in 8-week old mice inoculated i.m. with 106 TCID50.
8-week old BALB/C | ||||||
Day 3 | Day 5 | Day 7 | Day of euthanasia1 | Total | ||
DUVV-NL07 | brain | 0/5 | 0/5 | 0/5 | 13/25 | 13/40 |
muscle | 0/5 | 0/5 | 0/5 | n.d. | 0/15 | |
RABV-PV | brain | 0/5 | 3/5 | 2/5 | 15/25 | 30/40 |
muscle | 0/5 | 0/5 | 0/5 | 4/5 | 4/20 | |
SHBRV-18 | brain | 0/5 | 1/5 | n.d. | 19/20 | 20/30 |
muscle | 0/5 | 0/5 | n.d. | 5/5 | 5/15 |
The number of positive animals (viral RNA) per total number of animals tested is indicated.
Day of euthanasia varied between the three viruses (day 9–17 for DUVV-NL07, day 8–17 for RABV-PV and day 6–9 for SHBRV-18). See also Figure 4, survival curves.