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. 2012 May 24;7(5):e37722. doi: 10.1371/journal.pone.0037722

Figure 3. Neonatal N+LT nasal immunization primed for an early anti-N Ab response after the RSV challenge.

Figure 3

Mice vaccinated as neonates as in Fig.1 were bled before (day 0) and 5 or 8 days after the viral challenge with hRSV-A2 (d5 or d8 p.i.). Serum anti-N antibody titers were assessed by an endpoint dilution ELISA assay on plates coated with N using HRPO-conjugated rabbit anti-mouse Ig(H+L) Abs. Individual titers and the mean titer for day 0 (white circles, dotted line), d5 p.i. (grey circles, plain line) and d8 p.i. (black circles, plain line) are figured. Man-Whitney U-test was used for comparison of titers at day 0, 5 and 8 p.i. for each group (** p<0.01; *** p<0.001).