Figure 6.

Reduction in the writhing reflex (WR) evoked by balloon distention of the duodenum after a DC lesion. (a) The intensities of the WR evoked by graded distention (by 0.1 to 0.7 ml) of the duodenum are shown. No differences in the behavioral response were seen between rats tested before the sham surgery (pre-SH) and rats tested after the sham surgery (SH). The scale used was from 0 (normal) to 4 (stretching of the body, extension of the hind limbs). (b) The effect of the DC lesion on the behavioral response to duodenal distention is shown (prelesion vs. after lesion). (c) A comparison of the behavior in the sham surgery and lesion groups. The numbers of animals used are shown. ∗ indicate significant changes. [Figure reproduced with permission from ref. 13 (Copyright 1998, Lippincot Williams & Wilkins, http://lww.com).]