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. 2012 May 24;7(5):e38001. doi: 10.1371/journal.pone.0038001

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Northrup et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A) Left: Bilateral GCTs in a 6 week old female rat (black arrows: OGCTs). Right: Unilateral GCT in male rat (white arrow: non-neoplastic testes; red arrow: left TGCT). (B) HE staining of teratomas. Top left: ectodermal tissues in the ovarian teratoma of a 5-week-old female; neural tube formation (black star) and squamous epithelium (black arrow). Top right: mesodermal and endodermal tissues in the ovarian teratoma of a 9-week-old female; cartilage (white star), glandular structures (white arrow) and skeletal muscle (black arrow). Bottom left: heart muscle-like tissue from a contractile ovarian teratoma. Bottom right: immature neuronal tissue from a testicular teratoma of a 6-week-old male. (C) Rat gonads from 3-week-old siblings. Left: non-tumorous ter/ter testes are significantly smaller than wild type. Right: physiological wild type ovaries compared to an ovarian teratoma and an abnormal, cystic ovary (confirmed by histological section and HE staining).