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. 2012 May 24;7(5):e38001. doi: 10.1371/journal.pone.0038001

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Northrup et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A) Genotyping. The ter mutation disrupts a KpnI restriction site used for genotyping of the ter allele performing PCR amplification and restriction digest. KpnI digest (black arrows) cleaved the PCR product of 560 bp into 380 bp and 180 bp fragments, N negative control. (B) Kaplan-Meyer survival analysis of male and female WKY-Dnd1^ter/Ztm rats carrying heterozygous and homozygous ter alleles compared to wild type animals. (C) Sizes of TGCTs and OGCTs after 3, 6 and 9 weeks of age in homozygous WKY-Dnd1^ter/Ztm rats.