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. 2012 May 24;7(5):e38001. doi: 10.1371/journal.pone.0038001

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Northrup et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A) Box plot analysis of non-tumorous ovaries from WKY/Ztm and WKY-Dnd1^ter/Ztm with wild type (+/+), heterozygous (ter/+) and homozygous (ter/ter) genotype (**: p<0.01; ***: p<0.001). (B) HE staining of wild type (+/+, top panel) and mutant ovaries (ter/ter, bottom panel) of WKY-Dnd1^ter/Ztm rats at 6 weeks of age. While different stages of follicle maturation (top panel, left) and primary follicles with a central oocyte (top panel, right) were evident in the wild type ovary, few follicle-like structures without germ cells (bottom panel, right, arrows) remained in the ter/ter ovary.