Figure 6. Blood flow in ischemic limbs after BM reconstitution.

The blood flow of the ischemic hindlimbs of the chimeric mice after mismatched BMT was measured by laser Doppler perfusion imaging. The recovery of blood flow in the ischemic hindlimb significantly decreased in recipient WT mice receiving BM reconstitution with donor cells from KO mice. Conversely, the blood flow in the ischemic hindlimb significantly improved in recipient KO mice receiving BM reconstitution with donor cells from WT mice (n = 5 animals/group).