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Role of the P2Y2R in proinflammatory cytokine release
| oAβ1–42 (1 μM) | TNF-α (pg/ml) | IL-1β (pg/ml) | |
|---|---|---|---|
| Control | – | 20 | 28 |
| Wild type | + | 95** | 115** |
| P2Y2R−/− | + | 35 | 41 |
WT and P2Y2R−/− mouse primary microglial cells were treated with oAβ1–42 (1 μM), incubated for 24 h, and supernatants were collected and analyzed for TNF-α and IL-1β by ELISA. Data represent means ± SEM (n = 3)
**p < 0.01 indicates a significant difference from untreated control
