Fig. 7.

Schematic illustration of the P2X7 membrane complex showing ATP causes dissociation of nonmuscle myosin from the complex. P2X7 in its inactivated state forms a tight molecular complex with NMMHC-IIA. Once P2X7 is activated by extracellular ATP, NMMHC-IIA slowly dissociates from the complex over 10–15 min. In contrast, Ro-52 remains associated with P2X7. The full-length P2X7 structure modeling is predicted by I-TASSER online server (http://zhanglab.ccmb.med.umich.edu/I-TASSER/). The other protein structures are obtained from RCSB PDB (http://www.pdb.org/pdb/home/home.do) and EMBL-EBI (http://www.ebi.ac.uk/Databases/structure.html)