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. Author manuscript; available in PMC: 2013 Jul 17.
Published in final edited form as: Oncogene. 2012 Feb 20;32(3):286–295. doi: 10.1038/onc.2012.46

Figure 6.

Figure 6

Mechanism of synergy effects of ATM (25 μM) and VCR (5 nM) (a) Cell cycle analysis by FACS of cells treated with ATM and VCR. Mean ± SE were obtained from six independent experiments. Black line shows significant difference (P<0.05). (b) Rac1 activity is decreased by ATM, but not VCR. Mean ± SE were obtained from two independent experiments. Black line shows significant difference (P<0.05). (c) Immunofluorescence stain with Ki67, β-tubulin and DAPI showing non-proliferative multinuclear cells are increased by ATM and VCR. 200 cells were counted for each ICC experiment. Mean ± SE were obtained from three independent experiments. Black and gray lines show significant differences (P<0.05). (d) Schematic summary of ATM and VCR action. See Supplementary Figure S6 for representative ICC images corresponding to Figure 6c.