Table 3.
Univariate and Multivariable-adjusted Hazard of periprosthetic fracture following Revision Total Hip Replacement
| Variable | Total (n=6281) |
Periprosthetic Fractures (n=330) |
Univariate Hazard Ratio (95% CI) |
Multivariable a model 1 Hazard Ratio (95% CI) |
Multivariablea model 2 Hazard Ratio (95% CI) |
|---|---|---|---|---|---|
| Gender | p<0.001 | p<0.001 | p<0.001 | ||
| Male | 2,915 | 114 (4%) | 1.00 (ref) | 1.00 (ref) | 1.00 (REF) |
| Female | 3,366 | 216 (6%) | 1.63 (1.30, 2.04) | 1.67 (1.33, 2.10) | 1.68 (1.33, 2.11) |
| Age Category | p<0.001 | p<0.001 | p=0.002 | ||
| ≤60 | 1,985 | 144 (7%) | 1.00 (ref) | 1.00 (ref) | 1.00 (REF) |
| 61–70 | 1,678 | 83 (5%) | 0.66 (0.50, 0.86) | 0.64 (0.49, 0.85) | 0.67 (0.51, 0.88) |
| 71–80 | 1,932 | 75 (4%) | 0.59 (0.44, 0.78) | 0.57 (0.43, 0.76) | 0.60 (0.45, 0.80) |
| >80 | 686 | 28 (4%) | 0.82 (0.54, 1.23) | 0.74 (0.49, 1.12) | 0.79 (0.52, 1.20) |
| Body Mass Index, kg/m2 | p=0.27 | ||||
| Normal, < 25.0 | 1,833 | 114 (6%) | 1.00 (ref) | ||
| Overweight, 25–29.9 | 2,292 | 110 (5%) | 0.88 (0.67, 1.15) | ||
| Obese, 30–39.9 | 1,845 | 92 (5%) | 0.98 (0.53, 1.82) | ||
| Morbidly Obese, ≥40.0 | 245 | 11 (4%) | 0.77 (0.59, 1.00) | ||
| Deyo-Charlson Index | p=0.003 | p<0.001 | p<0.001 | ||
| 0 | 3,530 | 172 (5%) | 1.00 (ref) | 1.00 (ref) | 1.00 (REF) |
| 1 | 1,176 | 62 (5%) | 1.13 (0.85, 1.51) | 1.16 (0.87, 1.55) | 1.22 (0.91, 1.64) |
| 2 | 708 | 39 (6%) | 1.31 (0.92, 1.85) | 1.46 (1.03, 2.07) | 1.52 (1.06, 2.18) |
| 3+ | 867 | 57 (7%) | 1.75 (1.30, 2.37) | 2.03 (1.50, 2.75) | 2.08 (1.52, 2.86) |
| Operative Diagnosis | p<0.001 | p<0.001 | p<0.001 | ||
| Failure: Loose/Wear/Osteolysis | 4,173 | 221 (5%) | 1.00 (ref) | 1.00 (ref) | 1.00 (REF) |
| Failure: Previous Surgery | 713 | 35 (5%) | 1.08 (0.76, 1.54) | 1.14 (0.80, 1.63) | 1.19 (0.83, 1.70) |
| Failure: Fracture | 484 | 37 (8%) | 1.85 (1.30, 2.62) | 1.78 (1.25, 2.53) | 1.86 (1.30, 2.64) |
| Failure: Dislocation | 719 | 27 (4%) | 1.01 (0.68, 1.51) | 0.94 (0.63, 1.40) | 0.92 (0.61, 1.38) |
| Failure: Nonunion | 31 | 6 (19%) | 6.00 (2.66, 13.53) | 5.75 (2.54, 12.99) | 5.79 (2.55, 13.14) |
| Failure: Infection | 90 | 1 (1%) | 0.44 (0.06, 3.13) | 0.38 (0.05, 2.71) | 1.19 (0.83, 1.70) |
| Failure: Other | 71 | 3 (4%) | 0.81 (0.26, 2.52) | 0.72 (0.23, 2.26) | 0.77 (0.25, 2.41) |
| ASA class | p=0.06 | p=0.14 | |||
| 1 | 172 |
17 (10%) | 1.00 (ref) |
1.00 (REF) | |
| 2 | 2,961 | 172 (6%) | 0.71 (0.43, 1.18) | 0.75 (0.45, 1.26) | |
| 3 | 3,018 | 132 (4%) | 0.62 (0.38, 1.03) | 0.64 (0.38, 1.09) | |
| 4 | 97 | 7 (7%) | 1.39 (0.58, 3.36) | 1.20 (0.48, 3.09) | |
| Prior Cardiac event | p=0.43 | ||||
| No | 5,481 | 301 (5%) | 1.00 (ref) | ||
| Yes | 800 | 29 (4%) | 0.86 (0.58, 1.25) | ||
| Prior Thromboembolic Event | p=0.16 | p=0.13 | |||
| No | 6,043 | 325 (5%) | 1.00 (ref) | 1.00 (REF) | |
| Yes | 238 | 5 (2%) | 0.53 (0.22, 1.28) | 0.50 (0.21, 1.23) |