Table 3.
Coronary perfusion pressure (CPP) calculations for successive defibrillations attempts with and without ROSC (return of spontaneous circulation). CPP given as mean ± SEM.
| 1st Attempt (n = 123) | 2nd Attempt (n = 81) | 3rd Attempt (n = 51) | 4th Attempt (n = 33) | 5th Attempt (n = 19) | 6th Attempt (n = 7) | 7th Attempt (n = 2) | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ROSC (n =43) | No ROSC (n = 80) | ROSC (n = 64) | No ROSC (n = 17) | ROSC (n = 42) | No ROSC (n = 9) | ROSC (n = 2) | No ROSC (n = 31) | ROSC (n = 1) | No ROSC (n = 18) | ROSC (n = 2) | No ROSC (n = 5) | ROSC (n = 1) | No ROSC (n = 1) | |
| Threshold CPP (mmHg)* | 33.6 ± 1.8 | 18.2 ± 2.0 | 28.3 ± 4.5 | 12.5 ± 1.9 | 26.5 ± 3.3 | 14.8 ± 2.5 | 28.1 ± 3.9 | 11.3 ± 2.4 | 14.3# | 2.9 ± 3.5 | 30.5 ± 3.5 | 5.8 ± 3.9 | 29.9# | 0.3# |
| Delta CPP (mmHg) | 29.2 ± 1.6 | 14.8 ± 1.9 | 1.0 ± 1.6 | 0.1 ± 0.5 | 2.8 ± 2.2 | 3.6 ± 1.4 | 4.3 ± 1.6 | −0.1 ± 1.5 | −8.9# | −1.0 ± 1.2 | 0.2 ± 7.1 | −0.6 ± 0.6 | −1.1# | −1.0# |
| Cumulative Delta CPP (mmHg)* | 29.2 ± 1.6 | 14.8 ± 1.9 | 22.5 ± 4.6 | 9.7 ± 1.7 | 23.6 ± 3.0 | 11.9 ± 2.2 | 27.5 ± 1.6 | 7.9 ± 2.4 | 9.5# | −2.0 ± 3.7 | 26.0 ± 2.3 | 3.8 ± 3.0 | 26.6# | −0.3# |
| Dose CPP (mmHg)* | 8,405.5 ± 555.9 | 4,315.9 ± 480.5 | 2,642.3 ± 454.3 | 1,360.5 ± 243.3 | 2,553.1 ± 476.0 | 1,581.8 ± 539.1 | 2,325.7 ± 857.3 | 1,113.7 ± 794.1 | 2,220.8# | −287.6 ± 831.3 | 3,588.5 ± 1360.0 | 935.5 ± 588.3 | 4,671.4# | 1,494.9# |
| Cumulative Dose CPP (mmHg)* | 8,405.5 ± 555.9 | 4,315.9 ± 480.5 | 9,086.8 ± 1333.1 | 4,845.6 ± 608.8 | 10,830.5 ± 1763.6 | 6,016.8 ± 1023.1 | 9,193.0 ± 2408.1 | 8,324.5 ± 1443.4 | 23,889.5# | 8,688.3 ± 2136.4 | 23,173.8 ± 25.8 | 8,393.1 ± 1914.9 | 27,819.4# | 9,364.8# |
*
p < 0.05 for variation of CPP by defibrillation attempt for animals with ROSC.
#
n = 1, so unable to calculate SEM.