Table 4.

Predictive Value of CPP (coronary perfusion pressure) for ROSC (return of spontaneous circulation) based on multiple variable logistic regression modeling using five different conceptual models (threshold, delta, cumulative delta, dose, and cumulative dose).

	ROSC
	Odds Ratio	95% Confidence Interval	p-value
Threshold
Threshold CPP (mmHg)	1.06	1.04, 1.08	< 0.001
Shock number	0.86	0.67, 1.12	0.28
Experimental Design*
1	0.14	0.05, 0.36	< 0.001
2	0.53	0.13, 2.13	0.37
3	0.54	0.23, 1.27	0.16
4	4.80	1.73, 13.34	0.01
5	0.40	0.13, 1.18	0.10
6	0.97	0.34, 2.74	0.95
Delta
Delta CPP (mmHg)	1.04	1.01, 1.06	0.01
Shock number	0.96	0.73, 1.26	0.77
Experimental Design*
1	0.28	0.11, 0.71	0.01
2	0.71	0.18, 2.88	0.64
3	0.35	0.16, 0.79	0.01
4	5.26	1.93, 14.37	0.01
5	0.60	0.21, 1.66	0.21
6	1.43	0.54, 3.82	0.47
Cumulative Delta
Cumulative Delta CPP (mmHg)	1.06	1.04, 1.09	< 0.001
Shock number	0.85	0.66, 1.10	0.23
Experimental Design*
1	0.16	0.06, 0.41	< 0.001
2	0.43	0.10, 1.80	0.25
3	0.59	0.25, 1.39	0.23
4	4.33	1.56, 12.00	0.01
5	0.40	0.13, 1.19	0.10
6	1.22	0.44, 3.39	0.71
Dose
Dose CPP (1000 mmHg^2)	1.22	1.12, 1.34	< 0.001
Shock number	0.02	0.79, 1.33	0.88
Experimental Design*
1	0.15	0.06, 0.40	< 0.001
2	1.31	0.37, 4.69	0.68
3	0.42	0.18, 0.95	0.04
4	6.55	2.36, 18.24	< 0.001
5	0.66	0.23, 1.87	0.43
6	1.05	0.37, 2.96	0.93
Cumulative Dose
Cumulative Dose CPP (1000 mmHg^2)	1.18	1.10, 1.27	< 0.001
Shock number	0.55	0.40, 0.75	< 0.001
Experimental Design*
1	0.29	0.13, 0.65	0.01
2	1.58	0.45, 5.58	0.48
3	0.56	0.24, 1.32	0.18
4	6.33	2.27, 17.66	< 0.001
5	0.70	0.25, 1.98	0.50
6	0.88	0.31, 2.49	0.81

^*denotes p < 0.05.