Skip to main content
. Author manuscript; available in PMC: 2013 Sep 1.
Published in final edited form as: J Pineal Res. 2012 Feb 21;53(2):147–153. doi: 10.1111/j.1600-079X.2012.00981.x

Figure 1.

Figure 1

Melatonin does not affect the cell cycle of pfpk7− parasites. Parasite culture was treated with melatonin (MLT) (or vehicle) for 24 h. Proportions of the different parasite forms (ring, trophozoite and schizont) were determined by analyzing 2,000 cells in triplicates. The data show the average of three independent experiments. Addition of melatonin in Plasmodium falciparum 3D7 causes a modulation in the distribution of developmental stages in the intraerythrocytic cycle (A and C). However, this modulation is lost in pfpk7− parasites (clone B9) (B). Upon complementation of the KO parasite with an extra copy of the pfpk7 gene, the effect of melatonin is restored (D). Statistical analysis by ANOVA and Newman-Keuls Multiple Comparison Test. * p<0.05.