Table 1.
Heart function in TAC- and sham-operated Thbs4−/− and WT mice 2 wk after surgery
| Genotype | Function |
||||||
|---|---|---|---|---|---|---|---|
| EDV (μl) | ESV (μl) | EF (%) | IVRT (ms) | ET (ms) | FT (ms) | LV mass (mg) | |
| Sham WT | 30.4 ± 7.3 | 6.9 ± 3.0 | 77.6 ± 5.5 | 13.6 ± 1.2 | 34.2 ± 2.4 | 37.1 ± 3.4 | 156.8 ± 31.9 |
| Sham Thbs4−/− | 33.8 ± 11.5* | 10.5 ± 4.5* | 69.2 ± 6.1* | 14.0 ± 2* | 38.5 ± 4.0* | 39 ± 3.4 | 158.9 ± 35.1 |
| TAC WT | 42.0 ± 12.7 | 18.3 ± 10.9 | 58.2 ± 4.0 | 13.3 ± 0.8 | 38.7 ± 2.4 | 32.7 ± 1.6 | 182.7 ± 45.4 |
| TAC Thbs4−/− | 62.6 ± 20.6* | 36.5 ± 19.7* | 44.4 ± 13.8* | 16.9 ± 1.4* | 45.4 ± 5.2* | 33.2 ± 2.5 | 207.4 ± 41.4 |
Values are means ± sd.
*
P < 0.05 vs. WT; repeated-measures mixed models (n=5).