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Homotypic aggregation is increased following CD44 knockdown; additional CEA knockdown eliminates aggregation. A) LS174T parental and CD44-KD, CEA-KD, and CD44/CEA-KD cells were trypsinized and allowed to regenerate cell surface glycoproteins and aggregate under mild agitation for 2 h. Scale bar = 150 μm. B) Clusters made up of ≥4 cells were counted and compared with total number of cell singlets and clusters observed. *P < 0.05 vs. LS174T cells; §P < 0.05 vs. CD44/CEA-KD cells.
