Figure 2.

Distribution of hepatic transcripts encoding genes of the identified functional classes in 24-mo-old TTR transgenic mice. A) Transcripts that are relatively more abundant in livers of animals that have cardiac TTR deposition, represented as the proportion of the total number of increased transcripts that could be assigned to those functional groups (see Table 1). B) Distribution of hepatic transcripts that are increased in TTR transgenic mice that do not have cardiac TTR deposition. C) Hepatic transcriptional networks evident in the two groups of animals, as defined by Ingenuity software (Ingenuity Systems, Inc.). Genes depicted in red represent the network that is more highly activated in livers of animals in which there is cardiac TTR deposition. Shown in green is a transcriptional network found to be more highly expressed in the livers of TTR transgenic mice in which there is no cardiac deposition.