Figure 3.

Distribution of cardiac transcripts encoding genes of the identified functional classes in TTR transgenic mice. A) Relative abundance of transcripts increased in young TTR transgenic and nontransgenic control mice. Blue bars represent the proportion of transcripts increased in nontransgenic mice relative to those carrying the human wild-type TTR gene. Red bars represent the functional groups of transcripts showing relative increases in young transgenic relative to nontransgenic mice. Transgenic mice do not show cardiac deposition at this time. B) Green bars represent the functional groups of transcripts that are increased in hearts with deposition. Yellow bars represent the relatively increased transcripts, according to functional group, in transgenic animals that have no detectable cardiac TTR deposition. Numbers in parentheses in A and B indicate the number of transcripts that are included in the analysis (see Table 1). C) Major networks (as defined by Ingenuity analysis) expressed in the hearts with (red) and without (green) cardiac deposition.