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Transcriptional responses in an organ synthesizing TTR and an organ in which there is TTR deposition. Does this represent chaperoning at a distance? At 3 mo of age, there are no TTR deposits in the heart, but transcription patterns in both liver and heart differ from nontransgenic controls. At 2 yr of age, mice without patterns of hepatic transcription of elements of the proteostatic network show cardiac deposits and transcription patterns reflecting oxidative stress.
