Table 2.

Differences in functional groups of hepatic transcripts between experimental cohorts

Parameter	Young			Old
	YNTG > YTG	YTG > YNTG	P	OTGWD > OTGND	OTGND > OTGWD	P
Total transcript differences	230	392		121	75
Total identified transcript differences	171	355		106	68
Total identified and annotated differences	157	327		105	64
Inflammation	10	43	0.118	13	7	NS
Chaperones	0	2	NS	0	8	0.001
Proteasome	5	15	NS
Ubiquitin system	2	5	NS	3	1	NS
Autophagy	1	2	NS
Antioxidants	0	4	NS	7	2	NS
Apoptosis	5	9	NS	4	0	NS
Mitochondrial	5	15	NS	5	1	NS
Transcription factors	12	17	0.08	7	3	NS
Kinases	6	12	NS	6	1	NS
Extracellular matrix molecules	1	8	NS	0	1	NS
Ribosomal	0	1	NS
Mitochondrial ribosomal	1	2	NS
Proteases	2	0	NS
Channels	8	5	0.008
Secretory apparatus	4	23	0.17	5	5	NS
Peroxisomes	0	1	NS

YNTG, young (3 mo) nontransgenic; YTG, young transgenic; OTGWD, old (24 mo) transgenic with cardiac depositon; OTGND, old transgenic with no cardiac deposition; NS, not significant.