Table 3.
Differences in functional groups of cardiac transcripts related to age and presence of TTR deposition
| Parameter | Young |
Old |
||||
|---|---|---|---|---|---|---|
| YNTG > YTG | YTG > YNTG | P | OTGWD > OTGND | OTGND > OTGWD | P | |
| Total transcripts that differ | 294 | 257 | 533 | 139 | ||
| Total identified transcripts | 255 | 224 | 516 | 125 | ||
| Transcripts identified and annotated | 228 | 198 | 490 | 120 | ||
| Inflammation | 4 | 42 | 0.0001 | 24 | 61 | <0.0001 |
| Chaperones | 2 | 0 | NS | 17 | 1 | 0.03 |
| Proteasome/ubiquitin system | 7 | 1 | 0.03 | 25 | 2 | 0.01 |
| Autophagy | 4 | 0.052 | 3 | 1 | NS | |
| Anti-oxidants | 3 | 3 | NS | 13 | 0 | 0.02 |
| Apoptosis | 1 | 2 | NS | 21 | 1 | 0.01 |
| Mitochondrial | 15 | 4 | 0.007 | 64 | 2 | <0.0001 |
| Transcription factors | 14 | 19 | NS | 7 | 4 | NS |
| Kinases | 2 | 3 | NS | 12 | 3 | NS |
| Extracellular matrix | 2 | 2 | NS | 1 | 4 | 0.02 |
| Ribosomal | 3 | 10 | 0.09 | 4 | 0 | NS |
| Mitochondrial ribosomes | 3 | 0 | NS | 9 | 0 | 0.12 |
| Proteases | 3 | 4 | NS | NS | ||
| Channels | 8 | 3 | NS | 7 | 1 | NS |
| Secretory | 11 | 11 | NS | 16 | 1 | 0.05 |
| Peroxisomal | 5 | 1 | 0.11 | 4 | 0 | 0.58 |
| Ras-signalling | 14 | 6 | 0.06 | 6 | 1 | NS |
| Cardiac function | 24 | 15 | 0.08 | 12 | 6 | NS |
| Olfactory | 3 | 13 | 0.02 | 0 | 4 | 0.005 |
YNTG, young (3 mo) nontransgenic; YTG, young transgenic; otgwd, old (24 mo) transgenic with cardiac depositon; OTGND, old transgenic with no cardiac deposition; NS, not significant.