Table 4.

Differential expression of Xbp1s, Xbp1u, and hTTR in the hearts and livers of hTTR transgenic mice with and without cardiac TTR deposition and controls

Sample	Xbp1s		Xbp1u		hTTR
	Fold change	P	Fold change	P	Fold change	P value
Heart
Positive control vs. YTG	84.00
Positive control vs. OTGWD	353
Positive control vs. OTGND	521
YTG vs. OTGWD	−5.6	0.14	−1	0.76	49.048105	0.42
YTG vs. OTGND	−5.7	0.27	−2.5	0.36	26.037647	0.48
OTGWD vs. OTGND	−1	1	−2.4	0.37	−1.883738	0.62
Liver
YTG vs. YNTG	−7.4	0.23	−4.4	0.006	−104267	4E-07
YTG vs. OTGND	−8.5	0.05	−3.1	0.001	−5	0.0003
YTG vs. OTGWD	−16	0.02	−2.4	0.44	−1.8	0.011
OTGND vs. OTGWD	−1.9	0.15	−1.3	0.8	−2.6	0.001

YTG, young (3 mo) transgenic; OTGWD, old (24 mo) transgenic with cardiac depositon; OTGND, old transgenic with no cardiac deposition; YNTG, young nontransgenic.