Figure 1.

Surface expression of γ_c on T cells in various tissues of normal macaques. A) Representative dot plots showing the gating strategy for identifying γ_c⁺ CD3⁺ T lymphocytes and distribution of γ_c⁺ CD4⁺/CD8⁺ T-cell subsets, defined here as naïve, CD45RA⁺CCR7⁺; effector memory, CD45RA⁺/CD45RA⁻CCR7⁻; and central memory, CD45RA⁻CCR7⁺, in different tissues. Mes Ln, mesenteric lymph node; Jej LPL, jejunum lamina propria lymphocyte. B) Frequency of γ_c⁺ CD4⁺ (open bars) or γ_c⁺CD8⁺ (solid bars) as a percentage of gated CD3⁺ T cells in peripheral blood and various lymphoid tissues from normal Rhesus macaques. C) Group data showing the mean frequency of naive (CD45RA⁺CCR7⁺), central memory (Tcm; CD45RA-CCR7⁺), and effector memory (Tem; CD45RA⁺/CD45RA⁻CCR7⁻) gated γ_c⁺ CD4/CD8⁺ T cells in blood, mesenteric lymph node (LN), jejunum lamina propria lymphocyte (LPL), and vagina (n=7 for each tissue). Error bars represent means ± se. *P < 0.05 vs. peripheral blood.