Figure 3.

CBX and PBC blunt hypotonicity-induced ATP release in rat CFs; BFA has no such effect. A) CBX dose dependently inhibited ATP release in response to hypotonic stimulation, with maximal inhibition at 500 μM CBX. B) PBC (100 μM) inhibited ATP release (∼40%; P<0.01); greater concentrations had no additional effect. C) BFA had no effect on ATP release. In all experiments, CFs were incubated with vehicle (veh), CBX, PBC, or BFA for 30 min followed by 5 min stimulation with hypotonic medium. Data are presented as means ± se of ≥3 independent experiments. *P < 0.05, **P < 0.01.