Table 1.
Allele frequencies for the KCTD12 sequence screened in subjects with chronic tinnitus as compared to frequencies in a large control population.
| dbSNP ID | chr13 position | Major>minor allelesa | Variant amino acid | MAF in chronic tinnitus (2N)b | MAF in controls (2N)c | p |
|---|---|---|---|---|---|---|
| rs141180437 | 77,460,118 | C>T | P56S | 0.0000 (190) | 0.0000 (6972) | n.s. |
| rs116710456 | 77,460,080 | G>A | Q68Q | 0.0000 (190) | 0.0003 (6858) | n.s. |
| rs143013358 | 77,460,078 | C>T | P69L | 0.0000 (190) | 0.0000 (6844) | n.s. |
| rs694997 | 77,460,068 | G>A | L72L | 0.0000 (190) | 0.0003 (6872) | n.s. |
| rs146434030 | 77,460,065 | C>A | A73A | 0.0000 (190) | 0.0000 (6894) | n.s. |
| rs73237446 | 77,460,023 | C>T | F87F | 0.0053 (190) | 0.0089 (6890) | n.s. |
| rs141477426 | 77,460,015 | G>A | R90H | 0.0000 (190) | 0.0001 (6858) | n.s. |
| rs144225285 | 77,459,981 | C>T | L101L | 0.0000 (190) | 0.0000 (6756) | n.s. |
| rs34544607 | 77,459,750 | G>C | T178T | 0.0458 (262) | 0.0263 (5058) | 0.07 |
| rs139291676 | 77,459,507 | C>T | P259P | 0.0000 (262) | 0.0000 (7018) | n.s. |
| rs151278314 | 77,459,394 | C>T | T297M | 0.0000 (262) | 0.0000 (7020) | n.s. |
| rs142368706 | 77,459,383 | G>A | A301T | 0.0000 (262) | 0.0000 (7020) | n.s. |
| rs140689403 | 77,459,359 | A>G | S309G | 0.0000 (262) | 0.0001 (7020) | n.s. |
| rs41287030 | 77,459,221 | C>T | – | 0.0076 (262) | – | – |
Fisher's exact tests were used to address allelic association.
a
Nucleobases on the transcribed strand.
b
Call rates of 85% were achieved in the first round of screening amplicon b.
c
Reference population of European ancestry from the NHLBI GO Exome Sequencing Project. Data retrieved with the Exome Variant Server (URL: http://evs.gs.washington.edu/EVS/), accessed December 2011.
MAF, minor allele frequency.