Figure 3.

Increases in [Na⁺]_i by application of monensin potentiate single NMDA channel activity recorded in the cell-attached configuration. A shows the recording configuration. (B) A continuous record of NMDA channel P_o from neurons bathed with extracellular solution containing 50 mM Na⁺. (C) shows representative single-channel currents before and during monensin application. D Changes in P_o and mean open time (t_o) versus [Na⁺]_i during monensin application. For each Na⁺ concentration, six patches were tested. ∗, P < 0.05; ∗∗, P < 0.01, Mann–Whitney U test when compared with the channel activity at 0 mM Na⁺.